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This dataset contains synchronized two‑photon calcium‑imaging movies and loose‑patch cell‑attachment recordings from layer‑2 pyramidal cells and interneurons in the primary visual cortex of wild‑type mice. Recordings were performed in vivo while presenting moving grating stimuli to the contralateral eye. Indicators (jGCaMP8f/m/s, jGCaMP7f, XCaMPgf) were expressed via AAV injection under the synapsin‑1 promoter. Multiple neurons were recorded per mouse, and each cell was recorded multiple times in ~3‑minute sessions (movie & scan). A single .nwb file aggregates all data for a given cell. The dataset includes motion‑corrected two‑photon movies, raw loose‑patch electrophysiology traces for individual neurons, cell bodies and neuropil ROIs segmented by Suite2p, fluorescence traces for all ROIs, and detailed information about the moving grating stimulus presented to the contralateral eye.