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The PREVENT‑AD (Pre‑symptomatic Evaluation of Alzheimer’s Disease) cohort consists of cognitively healthy participants aged 55 + who are at risk of developing Alzheimer’s disease (AD) because a parent and/or sibling is affected. Since 2011, these high‑risk participants have been followed in a naturalistic study of the pre‑symptomatic phase of AD using multimodal measurements of various disease markers. A clinical trial testing a drug preventive agent has also been conducted. The PREVENT‑AD research team is now publicly releasing the data to support the growing community demand for AD pathogenesis research.