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This dataset is extracted from the NCBI‑maintained Human‑HIV Interaction dataset and contains over 16,000 pairs of interactions between HIV and human proteins. Fields include HIV protein product, HIV protein name, interaction type, human protein product, human protein name, reference list, description, HIV protein sequence, and human protein sequence. The dataset was created to train models that identify proteins interacting with HIV. It was manually curated by experts, which may bias it toward well‑studied proteins and known interactions.