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The released SYSU-CEUS dataset contains three types of focal liver lesions (FLL): 186 HCC instances, 109 HEM instances, and 58 FNH instances (i.e., 186 malignant and 167 benign instances). The dataset was collected by the First Affiliated Hospital of Sun Yat-sen University using an Aplio SSA-770A (Toshiba Medical Systems) device. All instances have a resolution of 768 × 576, originate from different patients, and exhibit substantial variation in appearance and enhancement patterns (e.g., size, contrast, shape, and location).