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GLENDA (Gynecologic Laparoscopy Endometriosis Dataset) comprises over 350 annotated images of endometriosis lesions from more than 100 gynecologic laparoscopic surgeries, plus over 13,000 unannotated non‑pathological images from more than 20 surgeries. It is designed for automated content analysis, particularly for endometriosis detection. The dataset offers binary and multi‑class classification configurations, each with detailed feature descriptions and split information. Annotations were produced by medical experts specializing in endometriosis treatment. Use is restricted to scientific research and prohibited for commercial purposes.